Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27364544 | 0.75 | SIGMAR1 (0.50) | SIGMAR1NPC1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL18112744 | 0.73 | LMNA (0.50) | SIGMAR1NPC1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL29006725 | 0.73 | SIGMAR1 (0.45) | SIGMAR1NPC1TDP1ALDH1A1SMN1; SMN2 | |
| SCHEMBL11828025 | 0.72 | SIGMAR1 (0.50) | SIGMAR1TSHRLTA4HSLC6A3 | |
| SCHEMBL23322456 | 0.71 | GRIK1 (0.47) | ALDH1A1SMN1; SMN2SLC6A3HPGD | |
| SCHEMBL10613686 | 0.71 | GRIK1 (0.47) | ALDH1A1SMN1; SMN2SLC6A3HPGD | |
| SCHEMBL27891876 | 0.71 | GRIK1 (0.51) | ALDH1A1SMN1; SMN2KDM4ESLC6A3 | |
| Hydrochloric Acid SCHEMBL8512322 | 0.71 | SIGMAR1 (0.49) | SIGMAR1TSHRLTA4HSLC6A3 | |
| SCHEMBL6570194 | 0.71 | MC4R (0.50) | SIGMAR1TSHRLTA4HSLC6A3 | |
| SCHEMBL11167774 | 0.70 | POLB (0.53) | SIGMAR1ALDH1A1KDM4ETSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101171009-A | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3- receptor ligands | BIOPROJET SOC CIV (FR) | 2008-04-30 | — | — | CN | claimed |
| CN-101171009-B | Use of non-imidazole alkylamines histamine h3- receptor ligands in treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia | BIOPROJET SOC CIV | 2012-11-07 | — | — | CN | disclosed |
| CN-101171009-A | Treatment of parkinson's disease obstructive sleep apnea, dementia with lewy bodies, vascular dementia with non-imidazole alkylamines histamine h3- receptor ligands | BIOPROJET SOC CIV (FR) | 2008-04-30 | — | — | CN | disclosed |