Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.33 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | TDO2 | P48775 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL28777074 | 0.81 | HSD17B10 (0.43) | ALDH1A1HSD17B10ACHEKIF11MET | |
| SCHEMBL27771054 | 0.81 | HSD17B10 (0.43) | ALDH1A1HSD17B10ACHEKIF11MET | |
| Water SCHEMBL28272876 | 0.80 | HSD17B10 (0.42) | ALDH1A1HSD17B10ACHEKIF11MET | |
| SCHEMBL5845451 | 0.79 | HSD17B10 (0.41) | ALDH1A1HSD17B10ACHEKIF11MET | |
| SCHEMBL27707899 | 0.79 | ALDH1A1 (0.41) | ALDH1A1HSD17B10ACHEKIF11MET | |
| SCHEMBL7211572 | 0.78 | ALDH1A1 (0.43) | ALDH1A1HSD17B10ACHEKIF11MET | |
| SCHEMBL10749956 | 0.76 | IMPDH2 (0.32) | KIF11 | |
| SCHEMBL3793637 | 0.76 | ALDH1A1 (0.56) | ALDH1A1HSD17B10ACHEMAPK1KIF11 | |
| SCHEMBL30972581 | 0.75 | HSD17B10 (0.44) | ALDH1A1HSD17B10ACHEKIF11KDM4E | |
| SCHEMBL17075458 | 0.73 | ALDH1A1 (0.46) | ALDH1A1HSD17B10MAPK1KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101558068-A | Phenylacetamides useful as protein kinase inhibitors | NOVARTIS AG (CH) | 2009-10-14 | — | — | CN | disclosed |
| CN-101291917-A | Diaryl urea derivatives for the treatment of protein kinase dependent diseases | NOVARTIS AG (CH) | 2008-10-22 | — | — | CN | disclosed |