Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 8/20 | 0.43 |
| ▸ | MLNR | O43193 | 3/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | F10 | P00742 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.32 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27709993 | 0.87 | PDK2 (0.52) | PDK2EPHX2TDP1CYP46A1POLB | |
| SCHEMBL27730506 | 0.85 | PDK2 (0.38) | PDK2SMN1; SMN2ALDH1A1KMT2AMEN1 | |
| SCHEMBL27730541 | 0.84 | POLB (0.37) | PDK2SMN1; SMN2USP30POLB | |
| SCHEMBL3182755 | 0.84 | PDK2 (0.47) | PDK2SMN1; SMN2KMT2AMEN1USP30 | |
| SCHEMBL27710057 | 0.77 | TP53 (0.55) | EPHX2SMN1; SMN2KMT2AMEN1POLB | |
| SCHEMBL27805795 | 0.75 | GPR119 (0.41) | SMN1; SMN2 | |
| SCHEMBL27621448 | 0.73 | MAPT (0.38) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL4875392 | 0.73 | USP30 (0.47) | EPHX2ALDH1A1KMT2AMEN1USP30 | |
| SCHEMBL27771460 | 0.73 | SCD (0.49) | — | |
| SCHEMBL28264100 | 0.72 | PDK2 (0.60) | PDK2MLNRSMN1; SMN2KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101227903-A | Novel 3-spirocyclic indolyl derivatives as ORL-1 receptor modulators | JANSSEN PHARMACEUTICA NV (BE) | 2008-07-23 | — | — | CN | disclosed |