SCHEMBL277305

SCHEMBL277305

Cc1ccc([SiH2][SiH2]c2ccc(C)cc2)cc1

nearest known ligand 0.57

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ACHE P22303 6/20 0.57
TDP1 Q9NUW8 1/20 0.57
CA2 P00918 2/20 0.43
LPL P06858 1/20 0.43
LIPG Q9Y5X9 1/20 0.43
ORAI1 Q96D31 1/20 0.43
ORAI2 Q96SN7 1/20 0.43
ORAI3 Q9BRQ5 1/20 0.43
TRPV6 Q9H1D0 1/20 0.43
ALDH1A1 P00352 4/20 0.42
CA1 P00915 2/20 0.42
CA7 P43166 1/20 0.42
CA9 Q16790 1/20 0.42
TSHR P16473 3/20 0.39
LMNA P02545 2/20 0.39
ALOX12 P18054 1/20 0.39
CYP2A6 P11509 2/20 0.36
IDO1 P14902 1/20 0.36
CES2 O00748 1/20 0.36
CES1 P23141 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8384837 0.87 ACHE (0.50) ACHETDP1CA2LPLLIPG
SCHEMBL26700635 0.84 ACHE (0.47) ACHETDP1CA2LPLLIPG
SCHEMBL8383878 0.84 ACHE (0.47) ACHETDP1CA2LPLLIPG
SCHEMBL8381861 0.82 ACHE (0.44) ACHETDP1CA2LPLLIPG
SCHEMBL208822 0.81 ACHE (0.61) ACHETDP1CA2LPLLIPG
SCHEMBL16301269 0.81 ACHE (0.61) ACHETDP1CA2LPLLIPG
SCHEMBL8384068 0.80 ACHE (0.42) ACHETDP1CA2LPLLIPG
Hydrochloric Acid SCHEMBL28008993 0.79 ACHE (0.57) ACHETDP1CA2LPLLIPG
SCHEMBL1054364 0.76
P-Xylene SCHEMBL460348 0.76 ACHE (1.00) ACHETDP1CA2LPLLIPG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8524582-B2 Silicon-germanium hydrides and methods for making and using same THE ARIZONA BOARD OF REGENTS (US) 2013-09-03 US disclosed
US-8518360-B2 Silicon-germanium hydrides and methods for making and using same ARIZONA BOARD OF REGENTS, A CORPORATE BODY ORGANIZED UNDER ARIZONA LAW, ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY 2013-08-27 US disclosed
EP-1951617-B1 NOVEL SILICON-GERMANIUM HYDRIDES AND METHODS FOR MAKING AND USING SAME UNIV ARIZONA (US) 2013-08-21 EP disclosed
EP-1960310-B1 SILICON-GERMANIUM HYDRIDES AND METHODS FOR MAKING AND USING SAME UNIV ARIZONA (US) 2013-08-21 EP disclosed
US-20130032857-A1 Silicon-Germanium Hydrides and Methods for Making and Using Same THE ARIZONA BOARD OF REGENTS, A BODY CORPORATE ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2013-02-07 US disclosed
US-20120217618-A1 Silicon-Germanium Hydrides and Methods for Making and Using Same The Arizona Board of Regents, a body corporated acting on behalf of Arizona State University (US) 2012-08-30 US disclosed
US-8216537-B2 Silicon-germanium hydrides and methods for making and using same ARIZONA BOARD OF REGENTS (US) 2012-07-10 US disclosed
US-8133802-B2 Silicon-germanium hydrides and methods for making and using same ARIZONA BOARD OF REGENTS (US) 2012-03-13 US disclosed
US-20100012972-A1 Silicon-Germanium Hydrides and Methods for Making and Using Same The Arizona Board of Regents, a body corparate acting onbehalf of Arizona State University (US) 2010-01-21 US disclosed
US-20090050935-A1 Silicon-Germanium Hydrides and Methods for Making and Using Same THE ARIZONA BOARD OFG REGENTS, A BODY CORPORATE ACTING ON BEHALF OF ARIZONA STATE UNIVERSITY (US) 2009-02-26 US disclosed