Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 3/20 | 0.51 |
| ▸ | AXL | P30530 | 1/20 | 0.47 |
| ▸ | TRPA1 | O75762 | 11/20 | 0.46 |
| ▸ | TRPM8 | Q7Z2W7 | 6/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.42 |
| ▸ | RXRB | P28702 | 1/20 | 0.42 |
| ▸ | RXRG | P48443 | 1/20 | 0.42 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.41 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477406 | 0.93 | NOS1 (0.53) | NOS1AXLTRPA1TRPM8TRPV1 | |
| SCHEMBL11577370 | 0.77 | NOS1 (0.60) | NOS1AXLTRPA1TRPM8PLK4 | |
| SCHEMBL6983718 | 0.75 | NOS1 (0.53) | NOS1AXLTRPA1TRPM8TRPV1 | |
| SCHEMBL22430426 | 0.73 | NOS1 (0.47) | NOS1AXLTRPA1TRPM8PLK4 | |
| SCHEMBL14738579 | 0.72 | NOS1 (0.50) | NOS1AXLTRPA1TRPM8TRPV1 | |
| SCHEMBL20078879 | 0.71 | NOS1 (0.45) | NOS1AXLTRPA1PLK4CHEK1 | |
| SCHEMBL24210664 | 0.69 | NOS1 (0.55) | NOS1PLK4CHEK1AURKADAPK3 | |
| SCHEMBL29520821 | 0.69 | TRPA1 (0.51) | NOS1TRPA1TRPM8TRPV1PLK4 | |
| SCHEMBL30402508 | 0.69 | NOS1 (0.55) | NOS1PLK4CHEK1AURKADAPK3 | |
| SCHEMBL3519434 | 0.69 | NOS1 (0.59) | NOS1TRPA1PLK4CHEK1AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101213194-A | Indazoles useful in treating cardiovascular diseases | WYETH CORP (US) | 2008-07-02 | — | — | CN | disclosed |