Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 8/20 | 0.44 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.43 |
| ▸ | GCGR | P47871 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27710726 | 0.82 | KDM4E (0.45) | HDAC1KCNH2CTSS | |
| SCHEMBL24378642 | 0.72 | KCNH2 (0.58) | DYRK1AIRAK4KCNH2FYNCTSS | |
| SCHEMBL10203124 | 0.70 | XDH (0.52) | DYRK1AIRAK4KCNH2CTSSCTSK | |
| SCHEMBL2559483 | 0.69 | TRPV3 (0.47) | DYRK1AIRAK4KCNH2FYNCTSS | |
| SCHEMBL27710727 | 0.69 | HDAC3 (0.43) | HDAC1 | |
| SCHEMBL13732539 | 0.68 | HDAC1 (0.50) | DYRK1AHDAC1GCGRPIM1MET | |
| SCHEMBL2555305 | 0.66 | DYRK1A (0.47) | DYRK1AKCNH2PIM1FYNCTSS | |
| SCHEMBL4591800 | 0.66 | CTSS (0.46) | DYRK1AIRAK4KCNH2FYNCTSS | |
| SCHEMBL12330967 | 0.65 | DYRK1A (0.51) | DYRK1AKCNH2CTSSCTSKCLK2 | |
| SCHEMBL14960645 | 0.65 | DYRK1A (0.49) | DYRK1AKCNH2CLK2HASPIN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101232873-A | Pharmaceutical composition comprising a dpp-iv inhibitor | HOFFMANN LA ROCHE (CH) | 2008-07-30 | — | — | CN | disclosed |