Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.60 |
| ▸ | HTR2C | P28335 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.60 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.51 |
| ▸ | IDO1 | P14902 | 1/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.51 |
| ▸ | NCF1 | P14598 | 3/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.49 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.46 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.46 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3618930 | 0.82 | HSP90AA1 (0.51) | MAPTHSP90AA1HSP90AB1IDO1PSMB5 | |
| SCHEMBL3566110 | 0.82 | MAPT (0.62) | MAPTHTR2AHTR2CSLC6A4NCF1 | |
| SCHEMBL3559935 | 0.82 | MAPT (0.62) | MAPTHTR2AHTR2CSLC6A4HSP90AA1 | |
| SCHEMBL3563724 | 0.80 | NCF1 (0.66) | MAPTHTR2AHTR2CSLC6A4NCF1 | |
| SCHEMBL3566951 | 0.79 | MAPT (0.58) | MAPTHTR2AHTR2CSLC6A4NCF1 | |
| SCHEMBL3622302 | 0.78 | HTR6 (0.65) | HTR2ANCF1ADRB2ALDH1A1KDM4E | |
| SCHEMBL28512817 | 0.77 | MAPT (1.00) | MAPTHTR2AHTR2CSLC6A4HSP90AA1 | |
| SCHEMBL28710430 | 0.77 | NCF1 (0.58) | MAPTHTR2AHTR2CSLC6A4NCF1 | |
| SCHEMBL15161248 | 0.77 | NCF1 (0.58) | MAPTHTR2AHTR2CSLC6A4NCF1 | |
| SCHEMBL1045944 | 0.75 | HTR2A (1.00) | MAPTHTR2AHTR2CSLC6A4NCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101243073-A | Piperazine-piperidine antagonists and agonists of the 5-HT1A receptor | WYETH CORP (US) | 2008-08-13 | — | — | CN | disclosed |