SCHEMBL2773349

SCHEMBL2773349

N#CCc1ccc(-c2ccc(F)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAOB P27338 3/20 0.47
NAAA Q02083 1/20 0.44
MMP3 P08254 1/20 0.43
PYCR1 P32322 1/20 0.42
IDO1 P14902 2/20 0.41
LOXL2 Q9Y4K0 1/20 0.41
TNF P01375 1/20 0.40
CYP11B1 P15538 2/20 0.39
CYP11B2 P19099 2/20 0.39
MAOA P21397 2/20 0.39
TAAR1 Q96RJ0 1/20 0.38
FLT3 P36888 1/20 0.38
MIF P14174 1/20 0.38
PTGS2 P35354 1/20 0.37
KMT2A Q03164 1/20 0.37
NPC1 O15118 1/20 0.37
RAB9A P51151 1/20 0.37
AGXT P21549 1/20 0.37
RXRA P19793 1/20 0.36
RXRB P28702 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL37742 0.93 IDO1 (0.46) MAOBIDO1LOXL2MAOATAAR1
Potassium Ion SCHEMBL27559718 0.88 IDO1 (0.42) MAOBIDO1LOXL2MAOATAAR1
SCHEMBL23137321 0.88 MMP3 (0.50) MMP3TNFCYP11B1CYP11B2FLT3
SCHEMBL196175 0.88 MMP3 (0.50) MMP3TNFCYP11B1CYP11B2FLT3
SCHEMBL9953772 0.86 IDO1 (0.41) MAOBIDO1LOXL2MAOATAAR1
SCHEMBL30439382 0.81 MMP3 (0.50) MMP3TNFCYP11B1CYP11B2FLT3
SCHEMBL18069859 0.81 MMP3 (0.70) MMP3CYP11B1CYP11B2TAAR1AGXT
SCHEMBL29644934 0.80 TNF (0.39) MMP3TNFCYP11B1CYP11B2FLT3
SCHEMBL2154504 0.80 KMT2A (0.47) MMP3LOXL2TNFFLT3KMT2A
SCHEMBL343612 0.79 MMP3 (0.53) NAAAMMP3PYCR1IDO1TNF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3283459-B1 MOLECULES HAVING PESTICIDAL UTILITY, AND INTERMEDIATES, COMPOSITIONS, AND PROCESSES, RELATED THERETO DOW AGROSCIENCES LLC (US) 2019-05-22 EP disclosed
EP-1590321-B1 ARYL ALKYL CARBAMATE DERIVATIVES PRODUCTION AND USE THEREOF IN THERAPY SANOFI AVENTIS (FR) 2010-04-28 EP disclosed
US-7632850-B2 2-amino-2-oxoethyl 1-(4'-fluoro-1,1'-biphenyl-4-yl)cyclopropylmethylcarbamate and 2-(methylamino)-2-oxoethyl 1-(4'-fluoro-1,1'-biphenyl-4-yl)cyclopropylmethylcarbamate; fatty acid amide (FAAH) hyrdrolase inhibitors; analgesics; neuropathic pain;psychological disorders; anticarcinogenic agents; AIDS SANOFI-AVENTIS (FR) 2009-12-15 US disclosed
US-20060014830-A1 Arylalkylcarbamate derivatives production and use thereof in therapy SANOFI-AVENTIS (FR) 2006-01-19 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060014830-A1 Arylalkylcarbamate derivatives production and use thereof in therapy CBR3, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, C5 MAOB 379/4885NAAA 1697/4885MMP3 2924/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.