Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK13 | O15264 | 5/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 5/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 5/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | IGFBP3 | P17936 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013185 | 0.82 | MAPK13 (0.39) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL4012971 | 0.70 | KMT2A (0.45) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL4014225 | 0.68 | MAPK13 (0.44) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL19641085 | 0.64 | KMO (0.38) | MAPK13MAPK12MAPK11MAPK14CES2 | |
| SCHEMBL19641109 | 0.63 | CDK2 (0.42) | MAPK14KMT2AMEN1CDK2 | |
| SCHEMBL19641316 | 0.63 | CCR4 (0.37) | MAPK13MAPK12MAPK11MAPK14CES2 | |
| SCHEMBL8634186 | 0.62 | MEN1 (0.41) | KMT2AMEN1 | |
| SCHEMBL27918522 | 0.62 | MEN1 (0.50) | KMT2AMEN1CES2CES1ALDH1A1 | |
| SCHEMBL2189708 | 0.62 | ALDH1A1 (0.57) | MAPK13MAPK12MAPK11MAPK14KMT2A | |
| SCHEMBL27854073 | 0.61 | MEN1 (0.49) | KMT2AMEN1LPAR1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101242832-B | Fused pyrazole as p38 MAP kinase inhibitors | HOFFMANN LA ROCHE | 2011-08-10 | — | — | CN | disclosed |
| CN-101242832-A | Fused pyrazole as p38 MAP kinase inhibitors | HOFFMANN LA ROCHE (CH) | 2008-08-13 | — | — | CN | disclosed |