Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.37 |
| ▸ | MMP9 | P14780 | 2/20 | 0.37 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27580465 | 0.89 | PDE5A (0.41) | MMP2MMP9PDE5AMMP8LMNA | |
| SCHEMBL27755585 | 0.84 | PDE5A (0.43) | MMP2MMP9PDE5ALMNAALDH1A1 | |
| SCHEMBL27735022 | 0.82 | MMP2 (0.36) | MMP2MMP9PDE5ALMNAKDM4E | |
| SCHEMBL27755589 | 0.78 | PRKCZ (0.31) | — | |
| SCHEMBL27598051 | 0.78 | NPSR1 (0.40) | LMNAALDH1A1RAB9AL3MBTL1HPGD | |
| SCHEMBL27755584 | 0.77 | PDE5A (0.40) | MMP2MMP9PDE5AMMP8LMNA | |
| SCHEMBL27734996 | 0.74 | MEN1 (0.36) | LMNAALDH1A1KDM4ERAB9AL3MBTL1 | |
| SCHEMBL27755567 | 0.73 | PDE5A (0.42) | MMP2MMP9PDE5AALDH1A1KDM4E | |
| SCHEMBL27735013 | 0.71 | PDE10A (0.37) | PDE5AALDH1A1KDM4EL3MBTL1 | |
| SCHEMBL27755569 | 0.66 | PRKCZ (0.36) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101486683-B | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | Sanitary Material R&D Management Co.,Ltd. (JP) | 2011-12-21 | — | — | CN | disclosed |
| CN-101486683-A | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |
| CN-100473647-C | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI CO LTD (JP) | 2009-04-01 | — | — | CN | disclosed |