Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 2/20 | 0.36 |
| ▸ | MMP9 | P14780 | 2/20 | 0.36 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | GRM7 | Q14831 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27735013 | 0.88 | PDE10A (0.37) | PDCD1CD274KDM4EPDE5ASLC16A3 | |
| SCHEMBL27580465 | 0.87 | PDE5A (0.41) | MMP2MMP9NPSR1TSHRPDE5A | |
| SCHEMBL27755585 | 0.83 | PDE5A (0.43) | MMP2MMP9NPSR1KDM4ETSHR | |
| SCHEMBL27598051 | 0.83 | NPSR1 (0.40) | SMN1; SMN2NPSR1NPC1PKMGRM5 | |
| SCHEMBL27735001 | 0.82 | MMP2 (0.37) | MMP2MMP9KDM4ETSHRHTT | |
| SCHEMBL27735005 | 0.81 | MEN1 (0.34) | PDCD1CD274 | |
| SCHEMBL27734996 | 0.75 | MEN1 (0.36) | SMN1; SMN2KDM4EHTTCYP3A4NPC1 | |
| SCHEMBL27755584 | 0.75 | PDE5A (0.40) | MMP2MMP9PDCD1CD274NPSR1 | |
| SCHEMBL27755567 | 0.73 | PDE5A (0.42) | MMP2MMP9NPSR1KDM4EHTT | |
| SCHEMBL27755569 | 0.71 | PRKCZ (0.36) | KDM4EGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101486683-B | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | Sanitary Material R&D Management Co.,Ltd. (JP) | 2011-12-21 | — | — | CN | disclosed |
| CN-101486683-A | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI R&D MAN CO LTD (JP) | 2009-07-22 | — | — | CN | disclosed |
| CN-100473647-C | Pyridazinone and triazinone compounds and their use as pharmaceutical formulations | EISAI CO LTD (JP) | 2009-04-01 | — | — | CN | disclosed |