Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | PMM2 | O15305 | 1/20 | 0.32 |
| ▸ | MPI | P34949 | 1/20 | 0.32 |
| ▸ | PHOSPHO1 | Q8TCT1 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27735501 | 0.88 | POLB (0.34) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL27756117 | 0.88 | MAPK14 (0.34) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL27756134 | 0.86 | POLB (0.33) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL27735513 | 0.86 | PTGS1 (0.35) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL27735516 | 0.85 | PMM2 (0.32) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL27756111 | 0.85 | POLB (0.34) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL27756112 | 0.84 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL27756110 | 0.74 | ALDH1A1 (0.33) | POLBHSD11B1PMM2MPIPHOSPHO1 | |
| SCHEMBL754189 | 0.74 | NR3C2 (0.45) | POLBPMM2MPIPHOSPHO1ALDH1A1 | |
| SCHEMBL27735498 | 0.73 | HSD11B1 (0.34) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101379048-B | Benzoxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORP | 2012-03-21 | — | — | CN | disclosed |
| CN-101379048-A | Benzo oxazines and related nitrogen-containing heterobicyclic compounds useful as mineralocorticoid receptor modulating agents | MITSUBISHI TANABE PHARMA CORP (JP) | 2009-03-04 | — | — | CN | disclosed |