Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24387803 | 0.83 | HTT (0.51) | HTTNPSR1ALDH1A1GFERGAA | |
| SCHEMBL2830746 | 0.80 | RAB9A (0.38) | HTTALDH1A1LMNA | |
| SCHEMBL27714548 | 0.79 | BMP1 (0.35) | HTTALDH1A1KMT2ALMNA | |
| SCHEMBL13188592 | 0.78 | HTT (0.43) | HTTNPSR1ALDH1A1GFERGAA | |
| SCHEMBL3718792 | 0.77 | HTT (0.43) | HTTNPSR1ALDH1A1GFERGAA | |
| SCHEMBL1785524 | 0.76 | HTT (0.50) | HTTNPSR1ALDH1A1GFERGAA | |
| SCHEMBL4213195 | 0.76 | HTT (0.50) | HTTNPSR1ALDH1A1GFERGAA | |
| SCHEMBL3951349 | 0.75 | HTT (0.51) | HTTNPSR1ALDH1A1GFERGAA | |
| SCHEMBL4223857 | 0.75 | HTT (0.64) | HTTNPSR1ALDH1A1GAAMEN1 | |
| SCHEMBL19384814 | 0.74 | HTT (0.48) | HTTNPSR1ALDH1A1GFERGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101248054-B | Thiazole derivatives and use thereof | MERCK SERONO SA | 2012-05-09 | — | — | CN | disclosed |
| CN-101248054-A | Thiazole derivatives and use thereof | SERONO LAB (CH) | 2008-08-20 | — | — | CN | disclosed |