Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMP1 | P13497 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.34 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830746 | 0.86 | RAB9A (0.38) | ROCK2RAB9ANPC1MTNR1AMTNR1B | |
| SCHEMBL27735562 | 0.79 | HTT (0.44) | LMNAKMT2AALDH1A1HTT | |
| SCHEMBL13189174 | 0.77 | HTT (0.33) | ROCK2LMNAALDH1A1HTT | |
| SCHEMBL3713266 | 0.76 | RAB9A (0.35) | RAB9ANPC1ALDH1A1HTT | |
| SCHEMBL2835865 | 0.73 | HTT (0.35) | HTT | |
| SCHEMBL22916970 | 0.72 | ROCK2 (0.43) | BMP1ROCK2RAB9AMTNR1AMTNR1B | |
| Hydrochloric Acid SCHEMBL3806743 | 0.72 | HTT (0.34) | HTT | |
| SCHEMBL11974048 | 0.71 | ALDH1A1 (0.42) | RAB9ANPC1ALDH1A1HTT | |
| SCHEMBL442506 | 0.70 | HTT (0.38) | BMP1ROCK2HTT | |
| SCHEMBL11167476 | 0.70 | ROCK2 (0.34) | BMP1ROCK2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101248054-B | Thiazole derivatives and use thereof | MERCK SERONO SA | 2012-05-09 | — | — | CN | claimed |
| CN-101248054-A | Thiazole derivatives and use thereof | SERONO LAB (CH) | 2008-08-20 | — | — | CN | claimed |
| CN-101248054-B | Thiazole derivatives and use thereof | MERCK SERONO SA | 2012-05-09 | — | — | CN | disclosed |
| CN-101248054-A | Thiazole derivatives and use thereof | SERONO LAB (CH) | 2008-08-20 | — | — | CN | disclosed |