SCHEMBL27735637

SCHEMBL27735637

CC(C)COC(=O)c1c[c]sc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 5/20 0.46
ALDH1A1 P00352 4/20 0.46
PLA2G1B P04054 1/20 0.40
ATG4B Q9Y4P1 1/20 0.40
GPR35 Q9HC97 1/20 0.38
JMJD6 Q6NYC1 1/20 0.37
MAPT P10636 2/20 0.37
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
HTT P42858 1/20 0.35
ADRB2 P07550 2/20 0.35
ADRB1 P08588 2/20 0.35
ADRB3 P13945 2/20 0.35
ADORA2B P29275 1/20 0.34
MCL1 Q07820 1/20 0.34
KDM4E B2RXH2 1/20 0.34
MAPK1 P28482 1/20 0.34
HSD17B10 Q99714 1/20 0.34
SCN1A P35498 1/20 0.34
SCN2A Q99250 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL128918 0.81 CA12 (0.47) TSHRALDH1A1MAPTNPC1RAB9A
SCHEMBL128073 0.78 LMNA (0.51) TSHRALDH1A1MAPTNPC1RAB9A
SCHEMBL6580266 0.74 ALDH1A1 (0.59) TSHRALDH1A1PLA2G1BATG4BGPR35
SCHEMBL110051 0.74 ALDH1A1 (0.64) TSHRALDH1A1PLA2G1BATG4BMAPT
SCHEMBL27667934 0.72 ALDH1A1 (0.62) TSHRALDH1A1PLA2G1BATG4BMAPT
SCHEMBL27668055 0.72 ALDH1A1 (0.62) TSHRALDH1A1PLA2G1BATG4BMAPT
SCHEMBL27668352 0.72 ALDH1A1 (0.62) TSHRALDH1A1PLA2G1BATG4BMAPT
SCHEMBL6954003 0.72 ALDH1A1 (0.49) TSHRALDH1A1PLA2G1BATG4BJMJD6
SCHEMBL6953148 0.70 ALDH1A1 (0.55) TSHRALDH1A1PLA2G1BATG4BJMJD6
Benzoic Acid 2-Methylpropyl Ester SCHEMBL298176 0.69 TSHR (0.69) TSHRALDH1A1PLA2G1BATG4BMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101374844-A Pyrrolopyridazinone compound UBE INDUSTRIES (JP) 2009-02-25 CN disclosed