Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.46 |
| ▸ | TNK2 | Q07912 | 5/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | FDPS | P14324 | 1/20 | 0.38 |
| ▸ | DRD1 | P21728 | 1/20 | 0.37 |
| ▸ | DRD5 | P21918 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264432 | 0.98 | ICMT (0.45) | ICMTTNK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13117192 | 0.85 | ICMT (0.46) | ICMTTNK2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL27736888 | 0.83 | KCNH2 (0.48) | ICMTTNK2MAPK1DRD1DRD5 | |
| SCHEMBL27736887 | 0.83 | KDR (0.43) | ICMTTNK2CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL27837718 | 0.83 | ICMT (0.40) | ICMTTNK2FGFR2 | |
| SCHEMBL28779311 | 0.82 | ICMT (0.41) | ICMTTNK2 | |
| SCHEMBL25100064 | 0.79 | TNK2 (0.41) | ICMTTNK2NPC1RAB9ALMNA | |
| SCHEMBL27736889 | 0.78 | ICMT (0.49) | ICMTRAB9AATM | |
| SCHEMBL28019125 | 0.76 | KCNH2 (0.55) | ICMTCYP2D6 | |
| SCHEMBL28143054 | 0.76 | ICMT (0.43) | ICMTTNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410114-B | A3 adenosine receptor allosteric modulators | US GOV HEALTH & HUMAN SERV (US) | 2012-07-04 | — | — | CN | disclosed |
| CN-101410114-A | A3 adenosine receptor allosteric modulators | US GOV HEALTH & HUMAN SERV (US) | 2009-04-15 | — | — | CN | disclosed |