Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | CDK1 | P06493 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ABL2 | P42684 | 1/20 | 0.37 |
| ▸ | CFTR | P13569 | 1/20 | 0.37 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | ATR | Q13535 | 1/20 | 0.36 |
| ▸ | ATRIP | Q8WXE1 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27736893 | 0.78 | ICMT (0.46) | ICMTATMRAB9A | |
| SCHEMBL11264432 | 0.77 | ICMT (0.45) | ICMTATMRAB9A | |
| SCHEMBL20817635 | 0.76 | ICMT (0.54) | ICMTHPGDIGF1RKCNH2 | |
| SCHEMBL30797720 | 0.76 | ICMT (0.54) | ICMTHPGDIGF1RKCNH2 | |
| SCHEMBL8695867 | 0.76 | CYP3A4 (0.54) | ICMTABL1EGFRCDK1SRC | |
| SCHEMBL20834416 | 0.73 | ICMT (0.69) | ICMTDRD2DRD3CYP11B1CYP11B2 | |
| SCHEMBL28019125 | 0.72 | KCNH2 (0.55) | ICMTCYP11B2KCNH2 | |
| SCHEMBL28019124 | 0.71 | KCNH2 (0.54) | ICMTCYP11B2KCNH2 | |
| SCHEMBL20817526 | 0.70 | ICMT (0.59) | ICMTKCNH2 | |
| SCHEMBL20817524 | 0.70 | ICMT (0.59) | ICMTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101410114-B | A3 adenosine receptor allosteric modulators | US GOV HEALTH & HUMAN SERV (US) | 2012-07-04 | — | — | CN | claimed |
| CN-101410114-A | A3 adenosine receptor allosteric modulators | US GOV HEALTH & HUMAN SERV (US) | 2009-04-15 | — | — | CN | claimed |
| CN-101410114-B | A3 adenosine receptor allosteric modulators | US GOV HEALTH & HUMAN SERV (US) | 2012-07-04 | — | — | CN | disclosed |
| CN-101410114-A | A3 adenosine receptor allosteric modulators | US GOV HEALTH & HUMAN SERV (US) | 2009-04-15 | — | — | CN | disclosed |