Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | SCD | O00767 | 1/20 | 0.45 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.44 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL378169 | 0.82 | SMN1; SMN2 (0.62) | SMN1; SMN2L3MBTL1NPC1RAB9AKDM4E | |
| Hydrochloric Acid SCHEMBL7489025 | 0.80 | ALOX15 (0.51) | SMN1; SMN2L3MBTL1NPC1RAB9AMEN1 | |
| SCHEMBL19981514 | 0.79 | MAPT (0.50) | SMN1; SMN2L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL10748367 | 0.76 | SMN1; SMN2 (0.46) | SMN1; SMN2L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL18912556 | 0.76 | HDAC1 (0.55) | NPC1RAB9ACSNK2A1KDM4EMEN1 | |
| SCHEMBL27716401 | 0.75 | HDAC1 (0.48) | SMN1; SMN2NPC1KDM4EMEN1KMT2A | |
| SCHEMBL1180559 | 0.74 | GAA (0.55) | SMN1; SMN2L3MBTL1NPC1RAB9ASCD | |
| SCHEMBL4290771 | 0.74 | NPC1 (0.79) | SMN1; SMN2L3MBTL1NPC1RAB9ASCD | |
| SCHEMBL12181081 | 0.73 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1NPC1RAB9AKDM4E | |
| SCHEMBL4881057 | 0.73 | AOC3 (0.64) | SMN1; SMN2NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273023-A | 5-substituted thiazol-2-ylamino compounds and compositions as protein kinase inhibitors | IRM LLC (BM) | 2008-09-24 | — | — | CN | disclosed |