Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.79 |
| ▸ | RAB9A | P51151 | 8/20 | 0.79 |
| ▸ | SCD | O00767 | 1/20 | 0.75 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.74 |
| ▸ | MEN1 | O00255 | 2/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.74 |
| ▸ | RECQL | P46063 | 1/20 | 0.74 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.74 |
| ▸ | AGER | Q15109 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 2/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.67 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.65 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.64 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.63 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.63 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.63 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.63 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL995829 | 0.88 | NPC1 (1.00) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL27594584 | 0.87 | NPC1 (0.97) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL16562033 | 0.86 | SCD (1.00) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL5502572 | 0.86 | AGER (0.76) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL5501384 | 0.85 | ADORA2A (0.90) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL3200814 | 0.85 | NPC1 (1.00) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL28801036 | 0.85 | NPC1 (0.72) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL3223685 | 0.85 | RAB9A (1.00) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL2307971 | 0.85 | RAB9A (0.72) | NPC1RAB9ASCDSMN1; SMN2LMNA | |
| SCHEMBL4293350 | 0.85 | RAB9A (0.77) | NPC1RAB9ASCDSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247593-A1 | N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2009-10-01 | — | — | US | disclosed |
| EP-1803455-A1 | N-thiazol-2-yl-benzamide derivatives | H.Lundbeck A/S (DK) | 2007-07-04 | — | — | EP | disclosed |
| EP-1682129-B1 | N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES | LUNDBECK & CO AS H (DK) | 2007-02-21 | — | — | EP | disclosed |
| EP-1682129-A1 | N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-07-26 | — | — | EP | disclosed |
| US-20060154974-A1 | N-thiazol-2-yl-benzamide derivatives | H. LUNDBECK A/S (DK) | 2006-07-13 | — | — | US | disclosed |
| WO-2005039572-A1 | N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES | H. LUNDBECK A/S (DK) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090247593-A1 | N-THIAZOL-2-YL-BENZAMIDE DERIVATIVES | ADORA2A, ADORA3, ADORA1 | NPC1 1022/4885RAB9A 2380/4885SCD 4684/4885 |
| US-20060154974-A1 | N-thiazol-2-yl-benzamide derivatives | ADORA2A, ADORA3, ADORA1 | NPC1 1022/4885RAB9A 2380/4885SCD 4684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.