Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 3/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.34 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.34 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.33 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.33 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.33 |
| ▸ | ITGAL | P20701 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27718126 | 0.87 | KMT2A (0.38) | F2HDAC8ITGB2ICAM1ITGAL | |
| SCHEMBL27739283 | 0.87 | EPHX2 (0.42) | HDAC8HPGDNR1I2KCNQ3KCNQ2 | |
| SCHEMBL3196554 | 0.85 | ALDH1A1 (0.43) | F2LMNANTSR1NR1I2ATM | |
| SCHEMBL27739287 | 0.81 | F2 (0.36) | F2CREBBPLMNANTSR1POLB | |
| SCHEMBL28771623 | 0.73 | EPHX2 (0.47) | HDAC8NR1I2KCNQ3KCNQ2KCNQ4 | |
| SCHEMBL3193216 | 0.73 | SERPINE1 (0.47) | F2CREBBPLMNANTSR1NR1I2 | |
| SCHEMBL3195564 | 0.71 | SERPINE1 (0.43) | HDAC8LMNA | |
| SCHEMBL3183923 | 0.71 | CRHBP (0.47) | GAAHPGDNR1I2KCNQ3KCNQ2 | |
| SCHEMBL3195492 | 0.71 | NTSR1 (0.62) | GAANTSR1 | |
| SCHEMBL27739284 | 0.69 | EPHX2 (0.42) | GAAHPGDNR1I2KCNQ3KCNQ2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101263115-A | Substituted indoles and use thereof | WYETH CORP (US) | 2008-09-10 | — | — | CN | claimed |
| CN-101263115-A | Substituted indoles and use thereof | WYETH CORP (US) | 2008-09-10 | — | — | CN | disclosed |