Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 1/20 | 0.50 |
| ▸ | CASP1 | P29466 | 4/20 | 0.49 |
| ▸ | CASP5 | P51878 | 4/20 | 0.49 |
| ▸ | CASP4 | P49662 | 3/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 9/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 8/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.46 |
| ▸ | APAF1 | O14727 | 8/20 | 0.45 |
| ▸ | MAPT | P10636 | 8/20 | 0.45 |
| ▸ | GAA | P10253 | 6/20 | 0.45 |
| ▸ | SENP8 | Q96LD8 | 5/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PPP1CA | P62136 | 3/20 | 0.44 |
| ▸ | NUDT1 | P36639 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | NSD2 | O96028 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2785735 | 0.89 | KMT5A (0.51) | CXCR4CASP1CASP5CASP4SENP6 | |
| SCHEMBL3476846 | 0.86 | CASP1 (0.50) | CASP1CASP5CASP4SENP6SENP7 | |
| SCHEMBL9215848 | 0.85 | HRH4 (0.56) | CASP1CASP5CASP4SENP6SENP7 | |
| SCHEMBL2773622 | 0.84 | HRH4 (0.44) | CXCR4CASP1CASP5CASP4SENP6 | |
| SCHEMBL2775160 | 0.83 | HRH4 (0.43) | CXCR4CASP1CASP5CASP4SENP6 | |
| SCHEMBL2773827 | 0.82 | HRH4 (0.43) | CASP1CASP5CASP4SENP6SENP7 | |
| SCHEMBL2772133 | 0.82 | HRH4 (0.42) | CASP1CASP5CASP4SENP6SENP7 | |
| SCHEMBL3475816 | 0.81 | HRH4 (0.46) | CASP1CASP5CASP4SENP6SENP7 | |
| SCHEMBL2991706 | 0.78 | CXCR4 (0.44) | CXCR4HRH4SMN1; SMN2NUDT1 | |
| SCHEMBL8963280 | 0.78 | ALDH1A1 (0.49) | CASP1CASP5CASP4HRH4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010130900-A2 | TRIAMINOPYRIMIDINE DERIVATIVES AS CDC25 PHOSPHATASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-11-18 | — | — | WO | disclosed |
| US-20100173910-A1 | TRIAMINOPYRIMIDINE CYCLOBUTENEDIONE DERIVATIVES USED AS PHOSPHATASE CDC25 INHIBITORS | IPDRN PHSTMS D.S.S. (FR) | 2010-07-08 | — | — | US | disclosed |
| EP-2178848-A1 | TRI-AMINO-PYRIMIDINE CYCLOBUTENEDIONE DERIVATIVES USED AS PHOSPHATASE CDC25 INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2010-04-28 | — | — | EP | disclosed |
| WO-2009034258-A1 | TRI-AMINO-PYRIMIDINE CYCLOBUTENEDIONE DERIVATIVES USED AS PHOSPHATASE CDC25 INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2009-03-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100173910-A1 | TRIAMINOPYRIMIDINE CYCLOBUTENEDIONE DERIVATIVES USED AS PHOSPHATASE CDC25 INHIBITORS | CDC25B, CDC25A, CDC25C | CXCR4 1151/4885CASP1 4179/4885CASP5 2010/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.