Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | CTSG | P08311 | 1/20 | 0.42 |
| ▸ | CMA1 | P23946 | 1/20 | 0.42 |
| ▸ | CTRC | Q99895 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27372191 | 0.83 | MEN1 (0.45) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL27749207 | 0.83 | BRD4 (0.41) | MMP2MGLLMEN1KMT2AGSK3A | |
| SCHEMBL6362998 | 0.82 | MAPT (0.41) | MAPTMMP2MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL15448415 | 0.74 | HTT (0.50) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL9678667 | 0.71 | ADRB1 (0.56) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL20121229 | 0.70 | ELANE (0.40) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL10192188 | 0.69 | ELANE (0.57) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL818462 | 0.68 | ADRB1 (0.58) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL25223859 | 0.67 | ELANE (0.48) | MAPTF2ELANECTSGCMA1 | |
| SCHEMBL5726036 | 0.67 | MAPT (0.56) | MAPTLMNAMMP2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101273018-A | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | WYETH CORP (US) | 2008-09-24 | — | — | CN | claimed |
| CN-101663281-A | Amino-5- [ 4- (difluoromethoxy) phenyl ] -5-phenylimidazolidinone compounds which inhibit the beta-secretase enzyme | WYETH CORP | 2010-03-03 | — | — | CN | disclosed |
| CN-101273018-A | Amino-5- [4- (difluoromethoxy) phenyl] -5-phenylimidazolone compounds as inhibitors of the beta-secretase (BACE) | WYETH CORP (US) | 2008-09-24 | — | — | CN | disclosed |