Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 4/20 | 0.50 |
| ▸ | CES1 | P23141 | 4/20 | 0.50 |
| ▸ | GPR84 | Q9NQS5 | 4/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Stearic Acid SCHEMBL6654230 | 0.89 | FABP3 (0.58) | CA1CES2CES1GPR84NFKB1 | |
| Stearic Acid SCHEMBL28189381 | 0.89 | FABP3 (0.58) | CA1CES2CES1GPR84NFKB1 | |
| Stearic Acid SCHEMBL27417983 | 0.88 | GPR84 (0.65) | GPR84FFAR1 | |
| L-Lactic Acid SCHEMBL27708897 | 0.87 | CA1 (0.50) | CA1CA2CES2CES1GPR84 | |
| L-Lactic Acid SCHEMBL27909066 | 0.87 | CA1 (0.50) | CA1CA2CES2CES1GPR84 | |
| L-Lactic Acid SCHEMBL16008431 | 0.87 | DNM1 (0.56) | CA1CA2CES2CES1GPR84 | |
| L-Lactic Acid SCHEMBL6072494 | 0.87 | CA1 (0.50) | CA1CA2CES2CES1GPR84 | |
| L-Lactic Acid SCHEMBL29256387 | 0.87 | SLC22A1 (0.54) | CA1CA2 | |
| L-Lactic Acid SCHEMBL27930783 | 0.87 | CA1 (0.50) | CA1CA2CES2CES1GPR84 | |
| L-Lactic Acid SCHEMBL27952813 | 0.86 | CES2 (0.48) | CA1CES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101227916-A | Compositions and methods for the prevention and treatment of conditions associated with inflammation | WELLGEN INC (US) | 2008-07-23 | — | — | CN | disclosed |