Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 6/20 | 0.50 |
| ▸ | PRMT5 | O14744 | 5/20 | 0.48 |
| ▸ | WDR77 | Q9BQA1 | 5/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.45 |
| ▸ | ADORA2B | P29275 | 3/20 | 0.45 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10365540 | 0.86 | PRMT5 (0.58) | AHCYPRMT5WDR77HIF1AADORA2A | |
| SCHEMBL28996759 | 0.83 | AHCY (0.49) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL28672423 | 0.82 | PRMT5 (0.53) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL6538405 | 0.82 | PRMT5 (0.53) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL7744261 | 0.82 | AHCY (0.46) | AHCYPRMT5WDR77ADORA2AADORA2B | |
| SCHEMBL5498775 | 0.82 | AHCY (0.51) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL28985735 | 0.82 | PRMT5 (0.50) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL9155536 | 0.82 | AHCY (0.51) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL7744279 | 0.82 | AHCY (0.47) | AHCYPRMT5WDR77HIF1ATMEM97 | |
| SCHEMBL11884247 | 0.81 | AHCY (0.53) | AHCYPRMT5WDR77HIF1ATMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117083303-A | Binding molecules with high affinity and/or specificity and methods of making and using the same | 阿拉码生物科学股份有限公司 | 2023-11-17 | — | — | CN | disclosed |
| CN-107970451-A | TLR activators and the treatment use of therapeutic alliance | 帆德制药股份有限公司 | 2018-05-01 | — | — | CN | disclosed |
| CN-103458902-B | Therapeutic uses of TLR agonists and combination therapies | 帆德制药股份有限公司 | 2017-11-07 | — | — | CN | disclosed |
| CN-103458902-A | Therapeutic uses of TLR agonists and combination therapies | VENTIRX PHARMACEUTICALS INC | 2013-12-18 | — | — | CN | disclosed |
| CN-101404883-A | Purine compounds and methods of use thereof | INOTEK PHARMACEUTICALS CORP (US) | 2009-04-08 | — | — | CN | disclosed |
| CN-101356159-A | Substituted isoquinoline-1, 3(2H,4H) -diones, 1-thio-1, 4-dihydro-2H-isoquinoline-3-ones and 1, 4-dihydro-3 (2H) -isoquinolones and their use as kinase inhibitors | WYETH CORP (US) | 2009-01-28 | — | — | CN | disclosed |