Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.41 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | IDH2 | P48735 | 3/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.36 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.36 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4706042 | 0.81 | HTT (0.49) | LMNAF10SMARCA2SMARCA4PBRM1 | |
| SCHEMBL4024455 | 0.81 | ALDH1A1 (0.51) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL4027973 | 0.79 | ALDH1A1 (0.50) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL4023577 | 0.79 | ALDH1A1 (0.50) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL4029065 | 0.79 | ALDH1A1 (0.50) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL4707178 | 0.79 | LMNA (0.46) | LMNAF10SMARCA2SMARCA4PBRM1 | |
| SCHEMBL4706419 | 0.76 | SLC6A9 (0.44) | LMNAF10KDM4EDPP4DPP8 | |
| SCHEMBL4025798 | 0.74 | GAA (0.56) | LMNAHTTKDM4EALDH1A1MAPT | |
| SCHEMBL4704511 | 0.74 | LMNA (0.59) | LMNAHTTALDH1A1MAPTHPGD | |
| SCHEMBL31481131 | 0.73 | ALDH1A1 (0.51) | LMNAF10SMARCA2SMARCA4PBRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101405265-A | Amido compounds and their use as pharmaceuticals | INCYTE CORP (US) | 2009-04-08 | — | — | CN | disclosed |