SCHEMBL277455

SCHEMBL277455

C=Cc1ccc(C(C)(C)C)c(Cl)c1Cl

nearest known ligand 0.35

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10435410 0.72
SCHEMBL4068356 0.72
SCHEMBL9124016 0.71 ALDH1A1 (0.39) ALDH1A1
SCHEMBL59762 0.70 ALDH1A1 (0.48) ALDH1A1
SCHEMBL13336066 0.70 CYP3A4 (0.40) ALDH1A1
SCHEMBL17160044 0.69 PTGS1 (0.30)
SCHEMBL10824246 0.69 GABRA1 (0.37) ALDH1A1
SCHEMBL1069961 0.68 CA2 (0.39) ALDH1A1
SCHEMBL7923839 0.68 ALOX5AP (0.35) ALDH1A1
SCHEMBL11661833 0.67 ALDH1A1 (0.38) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 73 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-4732464-B2 2011-07-27 JP claimed
EP-2255228-A1 LENSES COMPRISING AMPHIPHILIC MULTIBLOCK COPOLYMERS Bausch & Lomb Incorporated (US) 2010-12-01 EP claimed
US-20100069522-A1 LENSES COMPRISING AMPHIPHILIC MULTIBLOCK COPOLYMERS HUMAX PHARMACEUTICAL S.A. (CO) 2010-03-18 US claimed
EP-1828813-B1 POLYMERIZABLE SURFACTANTS AND THEIR USE AS DEVICE FORMING COMONOMERS BAUSCH & LOMB (US) 2010-02-10 EP claimed
WO-2009117374-A1 LENSES COMPRISING AMPHIPHILIC MULTIBLOCK COPOLYMERS BAUSCH & LOMB INCORPORATED (US) 2009-09-24 WO claimed
WO-2008057104-A1 USE OF THERMAL REVERSIBLE ASSOCIATIONS FOR ENHANCED POLYMER INTERACTIONS BAUSCH & LOMB INCORPORATED (US) 2008-05-15 WO claimed
WO-2007149083-A1 POLYMERIZABLE SURFACTANTS AND THEIR USE AS DEVICE FORMING COMONOMERS BAUSCH & LOMB INCORPORATED (US) 2007-12-27 WO claimed
EP-1828813-A1 POLYMERIZABLE SURFACTANTS AND THEIR USE AS DEVICE FORMING COMONOMERS Bausch & Lomb Incorporated (US) 2007-09-05 EP claimed
US-20070123602-A1 Use of thermal reversible associations for enhanced polymer interactions BAUSCH & LOMB INCORPORATED 2007-05-31 US claimed
US-20060275342-A1 Polymerizable surfactants and their use as device forming comonomers BAUSCH & LOMB INCORPORATED 2006-12-07 US claimed
US-5364918-A Surface modification of polymer objects BAUSCH & LOMB INCORPORATED (US) 1994-11-15 US claimed
EP-0559820-A1 SURFACE COATING OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1993-09-15 EP claimed
EP-0559784-A1 SURFACE-ACTIVE MACROMONOMERS. BAUSCH & LOMB (US) 1993-09-15 EP claimed
EP-0559809-A1 SURFACE MODIFICATION OF POLYMER OBJECTS. BAUSCH & LOMB (US) 1993-09-15 EP claimed
US-5219965-A Adding polymerizable surfactant to monomer mixture; contact lenses BAUSCH & LOMB INCORPORATED (US) 1993-06-15 US claimed
US-5177165-A Contact lenses BAUSCH & LOMB INCORPORATED (US) 1993-01-05 US claimed
US-5135297-A Immersing a contact lens in an aqueous dispersion of a polymerizable surfactant macromer, a crosslinker and a free radical catalyst and irradiating with UV light; wetting agents BAUSCH & LOMB INCORPORATED (US) 1992-08-04 US claimed
WO-1992009639-A2 SURFACE-ACTIVE MACROMONOMERS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO claimed
WO-1992009644-A1 SURFACE MODIFICATION OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO claimed
WO-1992009650-A1 SURFACE COATING OF POLYMER OBJECTS BAUSCH & LOMB INCORPORATED (US) 1992-06-11 WO claimed