Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.60 |
| ▸ | TOP2A | P11388 | 4/20 | 0.60 |
| ▸ | TOP2B | Q02880 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.54 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.54 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.54 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL541543 | 0.98 | ALDH1A1 (0.62) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL2108243 | 0.96 | ALDH1A1 (0.64) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL541544 | 0.95 | ALDH1A1 (0.62) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| Hydrochloric Acid SCHEMBL28459278 | 0.95 | ALDH1A1 (0.62) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL4718738 | 0.91 | KDM4E (0.60) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL22506727 | 0.86 | ALDH1A1 (0.52) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| Fluoride SCHEMBL5143436 | 0.86 | KDM4E (0.66) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL501238 | 0.86 | KDM4E (0.69) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL29442121 | 0.86 | KDM4E (0.69) | ALDH1A1KDM4ETOP2ATOP2BLMNA | |
| SCHEMBL9844577 | 0.86 | KDM4E (0.56) | ALDH1A1KDM4ETOP2ATOP2BLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101535305-B | 5-hydroxymethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD | 2013-09-18 | — | — | CN | disclosed |
| CN-101535305-A | 5-hydroxymethyl-oxazolidin-2-one derivatives | ACTELION PHARMACEUTICALS LTD (CH) | 2009-09-16 | — | — | CN | disclosed |
| CN-101341126-A | Antibacterial active 5-chinolin derivative | MORPHOCHEM AG FUER KOM (DE) | 2009-01-07 | — | — | CN | disclosed |