Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 3/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4242463 | 0.83 | GPR119 (0.53) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL6148439 | 0.82 | MMP13 (0.54) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL34461284 | 0.82 | MMP13 (0.54) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL387604 | 0.81 | MMP13 (0.48) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL27769018 | 0.80 | GPR119 (0.50) | MMP13GPR119DPP4 | |
| SCHEMBL27769045 | 0.79 | MMP13 (0.49) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL27769007 | 0.78 | MMP13 (0.53) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL5649711 | 0.78 | ALDH1A1 (0.55) | MMP13GPR119NPC1ALDH1A1MAPT | |
| SCHEMBL1854582 | 0.77 | GPR119 (0.57) | GPR119ALDH1A1MAPTHTT | |
| SCHEMBL4771701 | 0.77 | MMP13 (0.52) | MMP13GPR119NPC1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |