Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of 1-Methoxy-4-Ethoxybenzene. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | NQO1 | P15559 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.53 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.51 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1-Methoxy-4-Ethoxybenzene SCHEMBL27321389 | 0.98 | ALDH1A1 (0.60) | MAPTALDH1A1NPC1KDM4ECYP1A2 | |
| 1-Methoxy-4-Ethoxybenzene SCHEMBL27727144 | 0.96 | MAPT (0.58) | MAPTALDH1A1NPC1KDM4ECYP1A2 | |
| 1-Methoxy-4-Ethoxybenzene SCHEMBL354674 | 0.85 | NQO1 (0.78) | MAPTALDH1A1NPC1KDM4ECYP1A2 | |
| 1,4-Dimethoxybenzene SCHEMBL28153762 | 0.83 | CA1 (0.54) | MAPTALDH1A1KDM4ESMN1; SMN2PARP10 | |
| 1,4-Dimethoxybenzene SCHEMBL28051166 | 0.82 | CA1 (0.68) | MAPTNPC1SMN1; SMN2PARP10RAB9A | |
| SCHEMBL9728442 | 0.82 | CES2 (0.73) | MAPTALDH1A1NPC1KDM4ECYP1A2 | |
| SCHEMBL11576081 | 0.82 | KMT2A (0.69) | MAPTALDH1A1NPC1KDM4ECYP1A2 | |
| SCHEMBL11234780 | 0.82 | CES2 (0.73) | MAPTALDH1A1NPC1KDM4ECYP1A2 | |
| Phenetole SCHEMBL8364233 | 0.81 | LTA4H (0.65) | MAPTNPC1CYP1A2SMN1; SMN2MAPK1 | |
| Phenetole SCHEMBL29242129 | 0.81 | LTA4H (0.65) | MAPTNPC1CYP1A2SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101302149-A | Synthetic method of 4-methoxyl phenoxyl alkylphenate | XIAOWEN LIANG (CN) | 2008-11-12 | — | — | CN | disclosed |