Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | RAD52 | P43351 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | YWHAG | P61981 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 7/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27944975 | 0.87 | MAPT (0.52) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL27666678 | 0.86 | MAPT (0.50) | MAPTKDM4ERAD52ALDH1A1HTT | |
| SCHEMBL28334260 | 0.85 | NR4A1 (0.43) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL28794456 | 0.84 | MEN1 (0.39) | MAPTKDM4ERAD52ALDH1A1HTT | |
| SCHEMBL28256698 | 0.84 | NPY2R (0.41) | MAPTKDM4ERAD52ALDH1A1GAA | |
| SCHEMBL27945501 | 0.84 | MAPT (0.33) | MAPTKDM4ERAD52ALDH1A1POLB | |
| SCHEMBL27730809 | 0.84 | MAPT (0.46) | MAPTKDM4EPOLBHTTGAA | |
| SCHEMBL27751352 | 0.83 | MAPT (0.45) | MAPTKDM4EALDH1A1HTTGAA | |
| SCHEMBL28806302 | 0.80 | ALDH1A1 (0.59) | MAPTALDH1A1HTTGAASMN1; SMN2 | |
| SCHEMBL993225 | 0.80 | MAPT (0.55) | MAPTKDM4ERAD52ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103443102-A | Bicyclic carboxamide inhibitors of kinases | ABBVIE INC | 2013-12-11 | — | — | CN | disclosed |
| CN-103415516-A | Bicyclic inhibitors of ALK | ABBOTT LAB | 2013-11-27 | — | — | CN | disclosed |
| CN-102796099-A | Imidazoquinolines as lipid kinase inhibitors | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |
| CN-101495477-A | Imidazoquinolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-29 | — | — | CN | disclosed |