Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | RBP4 | P02753 | 2/20 | 0.38 |
| ▸ | NPY2R | P49146 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | GFER | P55789 | 1/20 | 0.37 |
| ▸ | YWHAG | P61981 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27648774 | 0.86 | PHGDH (0.46) | MAPTRBP4NPY2RKDM4EMEN1 | |
| SCHEMBL27666678 | 0.85 | MAPT (0.50) | MAPTTHRBKDM4EMEN1ALOX15 | |
| SCHEMBL27748488 | 0.84 | MAPT (0.54) | MAPTSMN1; SMN2NPY2RTHRBKDM4E | |
| SCHEMBL27944975 | 0.84 | MAPT (0.52) | MAPTSMN1; SMN2NPY2RTHRBKDM4E | |
| SCHEMBL265716 | 0.81 | NR1H2 (0.51) | MAPTTP53SMN1; SMN2NPY2RNR1H2 | |
| SCHEMBL29665792 | 0.81 | NR1H2 (0.51) | MAPTTP53SMN1; SMN2NPY2RNR1H2 | |
| SCHEMBL28334260 | 0.81 | NR4A1 (0.43) | MAPTSMN1; SMN2NPY2RTHRBKDM4E | |
| SCHEMBL27769725 | 0.81 | SLC6A9 (0.48) | MAPTSMN1; SMN2THRBWDR5HTT | |
| SCHEMBL28794456 | 0.81 | MEN1 (0.39) | MAPTSMN1; SMN2THRBKDM4EMEN1 | |
| SCHEMBL28302825 | 0.81 | ALDH1A1 (0.53) | MAPTSMN1; SMN2NPY2RKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109311869-A | Pass through the conjugation of (CDK8) inhibitor of cyclin dependent kinase 8 and E3 ligase ligand degradation CDK8 and application method | 达纳－法伯癌症研究所公司 | 2019-02-05 | — | — | CN | disclosed |
| CN-103596953-B | Pyrido naphthyridine type PI3K and mTOR double inhibitor and preparation and application thereof | 山东轩竹医药科技有限公司 | 2016-10-19 | — | — | CN | disclosed |
| CN-102399233-B | Dual PI3K and mTOR inhibitor compounds | KBP BIOSCIENCES CO LTD | 2014-08-13 | — | — | CN | disclosed |
| CN-103626742-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2014-03-12 | — | — | CN | disclosed |
| CN-103443102-A | Bicyclic carboxamide inhibitors of kinases | ABBVIE INC | 2013-12-11 | — | — | CN | disclosed |
| CN-101370792-B | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC | 2013-03-20 | — | — | CN | disclosed |
| CN-102796099-A | Imidazoquinolines as lipid kinase inhibitors | NOVARTIS AG | 2012-11-28 | — | — | CN | disclosed |
| CN-102399233-A | PI3K and mTOR dual inhibitor compound | KBP BIOSCIENCES CO LTD | 2012-04-04 | — | — | CN | disclosed |
| CN-102382128-A | Three-ring fused PI3K and mTOR dual inhibitor | KBP BIOSCIENCES CO LTD | 2012-03-21 | — | — | CN | disclosed |
| CN-101495477-A | Imidazoquinolines as lipid kinase inhibitors | NOVARTIS AG (CH) | 2009-07-29 | — | — | CN | disclosed |
| CN-101370792-A | Bi-aryl meta-pyrimidine inhibitors of kinases | TARGEGEN INC (US) | 2009-02-18 | — | — | CN | disclosed |