Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30753853 | 0.94 | KMT2A (0.45) | EPHX2KMT2ACHRM1LMNAHTT | |
| SCHEMBL14873810 | 0.85 | KMT2A (0.42) | KMT2ALMNAHTTDNM1ALDH1A1 | |
| SCHEMBL20393546 | 0.82 | KDM4E (0.46) | KMT2ACHRM1HTTDNM1ALDH1A1 | |
| SCHEMBL11020014 | 0.82 | TSHR (0.51) | EPHX2KMT2ACHRM1LMNAHTT | |
| SCHEMBL4500837 | 0.82 | KMT2A (0.41) | EPHX2KMT2AHTTDNM1TDP1 | |
| SCHEMBL11032609 | 0.82 | HTT (0.61) | KMT2ACHRM1HTTPKMALDH1A1 | |
| SCHEMBL10673469 | 0.82 | KMT2A (0.46) | KMT2AHTTDNM1TDP1 | |
| SCHEMBL13160340 | 0.82 | ALDH1A1 (0.49) | KMT2ALMNAALDH1A1NPC1 | |
| SCHEMBL16132855 | 0.81 | HRH3 (0.42) | EPHX2KMT2ACHRM1DNM1TDP1 | |
| SCHEMBL1651682 | 0.79 | LMNA (0.61) | EPHX2KMT2ACHRM1LMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101500569-A | HIF hydroxylase inhibitors for treatment of anemia of cancer | FIBROGEN INC (US) | 2009-08-05 | — | — | CN | disclosed |
| CN-101490041-A | 2-heterocycloamino-4-imidazolylpyrimidines as agents for the inhibition of cell proliferation | ASTRAZENECA AB (SE) | 2009-07-22 | — | — | CN | disclosed |