Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP10 | Q53GL7 | 9/20 | 0.43 |
| ▸ | PARP15 | Q460N3 | 8/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27689931 | 0.81 | RXFP1 (0.54) | MEN1KMT2ARXFP1 | |
| SCHEMBL1758227 | 0.79 | PARP15 (0.51) | PARP10PARP15MTNR1APARP2SLC6A2 | |
| SCHEMBL28756416 | 0.72 | RXFP1 (0.70) | MEN1KMT2ARXFP1 | |
| SCHEMBL27770177 | 0.67 | RXFP1 (0.46) | MEN1KMT2ARXFP1 | |
| SCHEMBL1758249 | 0.67 | NFE2L2 (0.42) | PARP10PARP15MTNR1ASLC6A2SLC6A4 | |
| SCHEMBL11310482 | 0.66 | SLC6A2 (0.48) | PARP10PARP15MTNR1ASLC6A2SLC6A4 | |
| SCHEMBL21123272 | 0.65 | LSS (0.64) | PARP10PARP15MEN1KMT2APARP2 | |
| SCHEMBL1758422 | 0.65 | MTNR1A (0.49) | PARP10PARP15MTNR1APARP2SLC6A2 | |
| SCHEMBL9966867 | 0.65 | PARP15 (0.55) | PARP10PARP15PARP2 | |
| SCHEMBL29053388 | 0.64 | PARP10 (0.49) | PARP10PARP15PARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101370787-B | 2- (phenyl or heterocyclyl) -1H-phenanthro [9,10-d ] imidazoles as mPGES-1 inhibitors | MERCK FROSST CANADA LTD | 2011-05-25 | — | — | CN | disclosed |
| CN-101370787-A | 2- (phenyl or heterocyclyl) -1H-phenanthro [9, 10-d ] imidazoles as mPGES-1 inhibitors | MERCK FROSST CANADA LTD (CA) | 2009-02-18 | — | — | CN | disclosed |