Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | MMP3 | P08254 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MYC | P01106 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.39 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.39 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7609085 | 0.82 | ERN1 (0.38) | MAPKAPK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL481107 | 0.80 | CLK4 (0.39) | CA1CA2EGLN2 | |
| SCHEMBL29956567 | 0.80 | CLK4 (0.39) | CA1CA2EGLN2 | |
| SCHEMBL7609087 | 0.78 | ERN1 (0.50) | MAP4K4CDK5KIF11 | |
| SCHEMBL25244672 | 0.77 | FDPS (0.44) | MAPKAPK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL30479916 | 0.77 | FDPS (0.44) | MAPKAPK2PSEN1PSEN2APH1BNCSTN | |
| SCHEMBL27863825 | 0.77 | ERN1 (0.39) | CA12CA2CA9CCNB2CDK1 | |
| SCHEMBL27751607 | 0.77 | MAP4K4 (0.46) | MAP4K4GSK3BPSEN1PSEN2APH1B | |
| SCHEMBL2084619 | 0.77 | EGFR (0.45) | MAP4K4MAPKAPK2 | |
| SCHEMBL29935212 | 0.77 | EGFR (0.45) | MAP4K4MAPKAPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101506149-A | Prolyl hydroxylase inhibitors and methods of use | PROCTER & GAMBLE (US) | 2009-08-12 | — | — | CN | claimed |
| CN-101506149-B | Prolyl hydroxylase inhibitors and methods of use | PROCTER & GAMBLE | 2012-11-14 | — | — | CN | disclosed |
| CN-101506149-A | Prolyl hydroxylase inhibitors and methods of use | PROCTER & GAMBLE (US) | 2009-08-12 | — | — | CN | disclosed |