Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 20/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 11/20 | 0.54 |
| ▸ | PGR | P06401 | 9/20 | 0.51 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL291539 | 0.89 | NR3C1 (0.68) | NR3C1CYP3A4PGRNR3C2KCNH2 | |
| SCHEMBL9987154 | 0.84 | NR3C1 (0.70) | NR3C1CYP3A4PGRNR3C2KCNH2 | |
| SCHEMBL6384914 | 0.81 | NR3C1 (0.56) | NR3C1CYP3A4PGRNR3C2 | |
| SCHEMBL292687 | 0.77 | NR3C1 (0.77) | NR3C1CYP3A4PGRNR3C2KCNH2 | |
| SCHEMBL27754149 | 0.77 | CHEK1 (0.42) | NR3C1CYP3A4 | |
| SCHEMBL6385232 | 0.76 | NR3C1 (0.71) | NR3C1CYP3A4PGRNR3C2 | |
| SCHEMBL5798281 | 0.74 | NR3C1 (0.49) | NR3C1CYP3A4PGRNR3C2KCNH2 | |
| SCHEMBL5801704 | 0.74 | NR3C1 (0.60) | NR3C1CYP3A4PGRNR3C2KCNH2 | |
| SCHEMBL3807894 | 0.72 | NR3C1 (0.64) | NR3C1CYP3A4PGRNR3C2KCNH2 | |
| SCHEMBL6383334 | 0.71 | NR3C1 (0.64) | NR3C1CYP3A4PGRNR3C2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2051736-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE | Bausch & Lomb Incorporated (US) | 2009-04-29 | — | — | EP | disclosed |
| WO-2008005686-A2 | COMPOSITIONS COMPRISING A DISSOCIATED GLUCOCORTICOID RECEPTOR AGONIST AND AN IMMUNOSUPPRESSIVE AGENT FOR TREATING DRY EYE | BAUSCH & LOMB INCORPORATED (US) | 2008-01-10 | — | — | WO | disclosed |