Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 1/20 | 0.66 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.63 |
| ▸ | RAB9A | P51151 | 8/20 | 0.60 |
| ▸ | NPC1 | O15118 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | GFER | P55789 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193488 | 0.91 | ROCK2 (0.73) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| SCHEMBL6804880 | 0.82 | PTPN1 (0.79) | RAB9ANPC1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL5384036 | 0.80 | ROCK2 (0.76) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| Nicotinanilide SCHEMBL29067673 | 0.80 | LMNA (0.83) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| Nicotinanilide SCHEMBL352439 | 0.80 | LMNA (0.83) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| SCHEMBL14880208 | 0.80 | ROCK2 (1.00) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| SCHEMBL10131874 | 0.79 | ROCK2 (0.73) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| SCHEMBL7329481 | 0.79 | ROCK2 (0.73) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| SCHEMBL13363308 | 0.79 | ROCK2 (0.73) | ROCK2ROCK1LMNAHIF1ARAB9A | |
| SCHEMBL29362556 | 0.79 | ROCK2 (0.73) | ROCK2ROCK1LMNAHIF1ARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101400699-A | Human glucagon-like-peptide-1 modulators and their use in the treatment of diabetes and related conditions | BRISTOL MYERS SQUIBB CO (US) | 2009-04-01 | — | — | CN | disclosed |