Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3750564 | 0.80 | KCNA5 (0.60) | TSHRALDH1A1GAATP53KCNA5 | |
| SCHEMBL27776326 | 0.79 | TDP1 (0.51) | TSHRALDH1A1GAAKCNA5KCNH2 | |
| SCHEMBL27755670 | 0.78 | KCNA5 (0.67) | KCNA5KCNH2 | |
| SCHEMBL27776327 | 0.78 | KCNA5 (0.53) | ALDH1A1TP53KCNA5KCNH2MAPT | |
| SCHEMBL28782889 | 0.77 | ALDH1A1 (0.58) | ALDH1A1KCNA5KCNH2NPSR1MCHR1 | |
| SCHEMBL3752979 | 0.77 | TSHR (0.49) | TSHRALDH1A1GAATP53KCNH2 | |
| SCHEMBL3758260 | 0.74 | SCN9A (0.58) | ALDH1A1TP53KCNA5KCNH2CYP3A4 | |
| SCHEMBL3758956 | 0.71 | SCN9A (0.52) | TSHRALDH1A1GAATP53KCNA5 | |
| SCHEMBL3747691 | 0.69 | P2RX7 (0.61) | TP53KCNH2NPSR1MCHR1THRB | |
| SCHEMBL27773071 | 0.69 | PDE6D (0.46) | TSHRALDH1A1GAATP53NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528690-A | Isoindoline derivatives for the treatment of arrhythmias | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | claimed |
| CN-101528690-A | Isoindoline derivatives for the treatment of arrhythmias | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | disclosed |