Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KCNA5 | P22460 | 11/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27755670 | 0.84 | KCNA5 (0.67) | KCNA5KCNH2 | |
| SCHEMBL27776327 | 0.83 | KCNA5 (0.53) | ALDH1A1KCNA5KCNH2MAPT | |
| SCHEMBL27776326 | 0.78 | TDP1 (0.51) | ALDH1A1KCNA5KCNH2TDP1 | |
| SCHEMBL3746135 | 0.77 | ALDH1A1 (0.65) | ALDH1A1NPSR1MCHR1LMNAKCNA5 | |
| SCHEMBL27755697 | 0.77 | TSHR (0.43) | ALDH1A1NPSR1MCHR1KCNA5KCNH2 | |
| SCHEMBL3752503 | 0.75 | ALDH1A1 (0.81) | ALDH1A1NPSR1MCHR1LMNAKCNA5 | |
| SCHEMBL1618368 | 0.72 | ALDH1A1 (1.00) | ALDH1A1NPSR1MCHR1LMNAMAPT | |
| SCHEMBL3750754 | 0.71 | NPSR1 (1.00) | ALDH1A1NPSR1MCHR1LMNAMAPT | |
| SCHEMBL1619214 | 0.71 | ALDH1A1 (0.62) | ALDH1A1NPSR1MCHR1LMNAMAPT | |
| SCHEMBL3760098 | 0.69 | LMNA (1.00) | ALDH1A1NPSR1MCHR1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101528690-A | Isoindoline derivatives for the treatment of arrhythmias | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | claimed |
| CN-101528690-A | Isoindoline derivatives for the treatment of arrhythmias | ASTRAZENECA AB (SE) | 2009-09-09 | — | — | CN | disclosed |