Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PAK4 | O96013 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | CSF1R | P07333 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27738778 | 0.85 | RAD52 (0.33) | — | |
| SCHEMBL27759470 | 0.82 | ESR1 (0.35) | DYRK1A | |
| SCHEMBL27701793 | 0.82 | MEN1 (0.34) | CA1CA2 | |
| SCHEMBL27701767 | 0.78 | LMNA (0.32) | — | |
| SCHEMBL27738780 | 0.77 | HIF1A (0.39) | — | |
| SCHEMBL27759478 | 0.77 | MEN1 (0.32) | — | |
| SCHEMBL27682688 | 0.73 | SRD5A1 (0.30) | — | |
| SCHEMBL27759475 | 0.71 | HSPB1 (0.42) | — | |
| SCHEMBL28001004 | 0.71 | CHEK1 (0.33) | CA12CA1CA2CA9CHEK1 | |
| SCHEMBL27948446 | 0.66 | CA12 (0.37) | CA12CA1CA2CA9CHEK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101421253-A | Quinazolin-4-one derivatives, process for their preparation and pharmaceutical compositions containing them | ASTRAZENECA AB (SE) | 2009-04-29 | — | — | CN | disclosed |