Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28320076 | 0.87 | SOAT1 (0.34) | LMNAHSD17B10GAAALOX15 | |
| SCHEMBL27925025 | 0.81 | LMNA (0.37) | LMNAHSD17B10ALOX15 | |
| SCHEMBL27893031 | 0.79 | ALDH1A1 (0.38) | LMNAHSD17B10ALOX15 | |
| SCHEMBL28831941 | 0.79 | LMNA (0.32) | LMNAHSD17B10 | |
| SCHEMBL18131107 | 0.79 | LMNA (0.38) | LMNAHSD17B10GAAALOX15 | |
| SCHEMBL28507146 | 0.79 | LMNA (0.38) | LMNAHSD17B10GAAALOX15 | |
| SCHEMBL224525 | 0.79 | LMNA (0.52) | LMNAHSD17B10GAAALOX15 | |
| SCHEMBL16214719 | 0.77 | LMNA (0.36) | LMNAHSD17B10GAAALOX15 | |
| SCHEMBL19874028 | 0.77 | LMNA (0.33) | LMNAHSD17B10 | |
| SCHEMBL19874029 | 0.77 | LMNA (0.33) | LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101541783-B | pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS, INC. (US) | 2014-10-01 | — | — | CN | disclosed |
| CN-101541783-A | Pyridinonyl PDK1 inhibitors | SUNESIS PHARMACEUTICALS (US) | 2009-09-23 | — | — | CN | disclosed |