Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 10/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PRKDC | P78527 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | METAP2 | P50579 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17287878 | 0.78 | PIK3CG (0.45) | KMT2AMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL27815576 | 0.76 | PIK3CA (0.46) | MAPTPOLBSMN1; SMN2ALDH1A1METAP1 | |
| SCHEMBL27921621 | 0.76 | CAMK2D (0.46) | MAPTALDH1A1METAP1HDAC6ALOX15 | |
| SCHEMBL18335244 | 0.75 | METAP1 (0.43) | KMT2AMAPTALDH1A1METAP1LMNA | |
| SCHEMBL27760169 | 0.74 | JAK2 (0.52) | POLBHTTPRKDCLMNAHDAC6 | |
| SCHEMBL17537245 | 0.74 | EGLN1 (0.39) | KMT2AMAPTSMN1; SMN2HTTALDH1A1 | |
| SCHEMBL27552396 | 0.73 | LMNA (0.51) | KMT2AMAPTSMN1; SMN2ALDH1A1METAP1 | |
| SCHEMBL27794443 | 0.70 | HDAC1 (0.42) | KMT2AMAPTSMN1; SMN2ALDH1A1GAA | |
| SCHEMBL27739794 | 0.70 | ATR (0.46) | KMT2ASMN1; SMN2HDAC6NPC1MEN1 | |
| SCHEMBL27815572 | 0.69 | HPGDS (0.51) | GAAHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101861313-B | Phenylaminopyrimidine compounds and their use | CYTOPIA RES PTY LTD | 2014-06-04 | — | — | CN | disclosed |
| CN-101861313-A | Phenylaminopyrimidine compounds and their use | CYTOPIA RES PTY LTD | 2010-10-13 | — | — | CN | disclosed |
| CN-101421250-A | 4-aryl-2-amino-pyrimidines or 4-aryl-2-aminoalkyl-pyrimidines as jak-2 modulators and pharmaceutical compositions containing them | EXELIXIS INC (US) | 2009-04-29 | — | — | CN | disclosed |