Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADH1B | P00325 | 1/20 | 0.44 |
| ▸ | ADH1C | P00326 | 1/20 | 0.44 |
| ▸ | ADH1A | P07327 | 1/20 | 0.44 |
| ▸ | ADH7 | P40394 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | ACP3 | P15309 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ANPEP | P15144 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13675824 | 0.83 | SIGMAR1 (0.44) | ADH1BADH1CADH1AADH7SMN1; SMN2 | |
| SCHEMBL9063693 | 0.83 | SIGMAR1 (0.44) | ADH1BADH1CADH1AADH7SMN1; SMN2 | |
| SCHEMBL170305 | 0.78 | SIGMAR1 (0.55) | SIGMAR1EPHX1IDO1CYP3A4MAPT | |
| SCHEMBL21835602 | 0.78 | SIGMAR1 (0.55) | SIGMAR1EPHX1IDO1CYP3A4MAPT | |
| SCHEMBL10797644 | 0.78 | SIGMAR1 (0.55) | SIGMAR1EPHX1IDO1CYP3A4MAPT | |
| SCHEMBL14495877 | 0.77 | SIGMAR1 (0.44) | SIGMAR1IDO1ACP3TSHRCYP1A2 | |
| SCHEMBL13675822 | 0.75 | SIGMAR1 (0.61) | ADH1BADH1CADH1AADH7SMN1; SMN2 | |
| SCHEMBL10696254 | 0.75 | SIGMAR1 (0.61) | ADH1BADH1CADH1AADH7SMN1; SMN2 | |
| SCHEMBL9063684 | 0.75 | SIGMAR1 (0.61) | ADH1BADH1CADH1AADH7SMN1; SMN2 | |
| SCHEMBL9063691 | 0.74 | SMN1; SMN2 (0.70) | ADH1BADH1CADH1AADH7SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101553474-B | Imidazolidinone and imidazolidinone derivatives as 11b-HSD1 inhibitors for diabetes | HOFFMANN LA ROCHE | 2013-02-27 | — | — | CN | disclosed |
| CN-101553474-A | Imidazolidinone and imidazolidinone derivatives as 11 b-HSD 1 inhibitors for diabetes | HOFFMANN LA ROCHE (CH) | 2009-10-07 | — | — | CN | disclosed |