Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.71 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.63 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.59 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.59 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.59 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.59 |
| ▸ | CA1 | P00915 | 1/20 | 0.58 |
| ▸ | CA2 | P00918 | 1/20 | 0.58 |
| ▸ | CA9 | Q16790 | 1/20 | 0.58 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30804503 | 0.84 | HSD17B10 (0.60) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL2203840 | 0.84 | NOTUM (0.83) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL7838147 | 0.84 | HSD17B10 (0.64) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL4869626 | 0.83 | MAPT (0.69) | HSD17B10NOTUMSMN1; SMN2KMT2AALDH1A1 | |
| SCHEMBL22196868 | 0.83 | HSD17B10 (0.75) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL7385259 | 0.82 | PDK1 (0.61) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL28631380 | 0.82 | HSD17B10 (0.70) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL24764176 | 0.81 | HSD17B10 (0.71) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL4863193 | 0.80 | MAPT (0.64) | HSD17B10NOTUMPDK1PDK2PDK3 | |
| SCHEMBL4869965 | 0.80 | MAPT (0.64) | HSD17B10NOTUMPDK1PDK2PDK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855215-B2 | Cyclic diaryl ureas suitable as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2010-12-21 | — | — | US | disclosed |
| US-20080039440-A1 | Cyclic Diaryl Ureas Suitable as Tyrosine Kinase Inhibitors | BOLD GUIDO | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039440-A1 | Cyclic Diaryl Ureas Suitable as Tyrosine Kinase Inhibitors | RET, ROS1, BRAF | HSD17B10 2798/4885NOTUM 4066/4885PDK1 637/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.