Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 3/20 | 0.61 |
| ▸ | PDK2 | Q15119 | 3/20 | 0.61 |
| ▸ | PDK3 | Q15120 | 3/20 | 0.61 |
| ▸ | PDK4 | Q16654 | 3/20 | 0.61 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6757671 | 0.96 | PDK1 (0.66) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL24011118 | 0.84 | LMNA (0.71) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL7668576 | 0.84 | PDK1 (0.56) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL2776090 | 0.82 | HSD17B10 (0.71) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL26763825 | 0.81 | PDK1 (0.61) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL6754913 | 0.80 | PDK1 (0.60) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL7382818 | 0.80 | NOTUM (0.62) | MAPTLMNANOTUMKDM4ETSHR | |
| SCHEMBL7838147 | 0.78 | HSD17B10 (0.64) | PDK1PDK2PDK3PDK4MAPT | |
| SCHEMBL16589863 | 0.77 | PDK1 (1.00) | PDK1PDK2PDK3PDK4 | |
| SCHEMBL6754157 | 0.76 | PDK1 (0.42) | PDK1PDK2PDK3PDK4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1000067-B1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | AVENTIS PHARMA SA (FR) | 2002-10-23 | — | — | EP | disclosed |
| EP-1000067-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | Aventis Pharma S.A. (FR) | 2000-05-17 | — | — | EP | disclosed |
| WO-1999005147-A1 | THIAZOLOBENZOHETEROCYCLES, PREPARATION AND MEDICINES CONTAINING SAME | RHONE-POULENC RORER S.A. (FR) | 1999-02-04 | — | — | WO | disclosed |