Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 5/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 1/20 | 0.38 |
| ▸ | RXRB | P28702 | 1/20 | 0.38 |
| ▸ | RXRG | P48443 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2771969 | 0.92 | FAAH (0.55) | FAAHCES1 | |
| SCHEMBL2776161 | 0.85 | FAAH (0.51) | FAAHCES1 | |
| SCHEMBL2773694 | 0.81 | BRS3 (0.36) | FAAHRXRARXRBRXRG | |
| SCHEMBL2771966 | 0.77 | FAAH (0.62) | FAAHCES1 | |
| SCHEMBL2771949 | 0.75 | RXRA (0.41) | RXRARXRBRXRG | |
| SCHEMBL2809171 | 0.74 | FAAH (0.56) | FAAH | |
| SCHEMBL2776774 | 0.72 | FAAH (0.82) | FAAHCES1 | |
| SCHEMBL1471369 | 0.69 | FAAH (0.75) | FAAHCES1 | |
| SCHEMBL2776235 | 0.69 | FAAH (0.57) | FAAHCES1 | |
| SCHEMBL2775416 | 0.67 | FAAH (0.57) | FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2152082-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147553-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-04 | — | — | WO | disclosed |