Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.44 |
| ▸ | WEE1 | P30291 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11258892 | 0.87 | ALDH1A1 (0.51) | ALDH1A1L3MBTL1GRIK1GRIK2BACE1 | |
| SCHEMBL11505491 | 0.84 | ALDH1A1 (0.69) | ALDH1A1L3MBTL1GRIK1GRIK2BACE1 | |
| SCHEMBL11690351 | 0.81 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1BACE1MTNR1AMTNR1B | |
| SCHEMBL11557912 | 0.81 | WEE1 (0.49) | ALDH1A1L3MBTL1GRIK1GRIK2CHEK1 | |
| SCHEMBL2122743 | 0.78 | CYP19A1 (0.66) | ALDH1A1L3MBTL1MTNR1AMTNR1BKMT2A | |
| SCHEMBL11690361 | 0.74 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1BACE1MTNR1AMTNR1B | |
| SCHEMBL11689668 | 0.73 | PTGS2 (0.55) | ALDH1A1L3MBTL1BACE1MTNR1AMTNR1B | |
| SCHEMBL10185825 | 0.72 | F10 (0.59) | KMT2A | |
| SCHEMBL8995303 | 0.72 | GRIK1 (0.52) | ALDH1A1L3MBTL1GRIK1GRIK2BACE1 | |
| SCHEMBL21735646 | 0.71 | ALDH1A1 (0.47) | ALDH1A1L3MBTL1GRIK1GRIK2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101575331-B | Preparation method of 5'-((5-MethoxyMethoxy-2- phenylindole-1-yl)methylene)-2'-oxo-3'- methylenetetrahydrofuran | SHANGHAI INST MATERIA MEDICA | 2011-07-20 | — | — | CN | claimed |
| CN-101575331-A | Preparation method of 5'-((5-methoxyl-2-phenyl indole-1-yl) methylene)-2'-oxo-3'-tetrahydrofurfuryl | SHANGHAI INST MATERIA MEDICA (CN) | 2009-11-11 | — | — | CN | claimed |
| CN-101575331-B | Preparation method of 5'-((5-MethoxyMethoxy-2- phenylindole-1-yl)methylene)-2'-oxo-3'- methylenetetrahydrofuran | SHANGHAI INST MATERIA MEDICA | 2011-07-20 | — | — | CN | disclosed |
| CN-101575331-B | Preparation method of 5'-((5-MethoxyMethoxy-2- phenylindole-1-yl)methylene)-2'-oxo-3'- methylenetetrahydrofuran | SHANGHAI INST MATERIA MEDICA | 2011-07-20 | — | — | CN | disclosed |
| CN-101575331-A | Preparation method of 5'-((5-methoxyl-2-phenyl indole-1-yl) methylene)-2'-oxo-3'-tetrahydrofurfuryl | SHANGHAI INST MATERIA MEDICA (CN) | 2009-11-11 | — | — | CN | disclosed |
| CN-101575331-A | Preparation method of 5'-((5-methoxyl-2-phenyl indole-1-yl) methylene)-2'-oxo-3'-tetrahydrofurfuryl | SHANGHAI INST MATERIA MEDICA (CN) | 2009-11-11 | — | — | CN | disclosed |