Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2775412 | 0.92 | FAAH (0.74) | FAAHCES1 | |
| SCHEMBL2775285 | 0.84 | FAAH (0.59) | FAAHCES1 | |
| SCHEMBL2776235 | 0.84 | FAAH (0.57) | FAAHCES1 | |
| SCHEMBL2772396 | 0.81 | FAAH (0.84) | FAAHCES1 | |
| SCHEMBL2775416 | 0.78 | FAAH (0.57) | FAAHCES1 | |
| SCHEMBL12472502 | 0.77 | FAAH (0.71) | FAAH | |
| SCHEMBL2771966 | 0.77 | FAAH (0.62) | FAAHCES1 | |
| SCHEMBL2774807 | 0.76 | FAAH (0.58) | FAAHCES1 | |
| SCHEMBL17067868 | 0.75 | FAAH (0.71) | FAAH | |
| SCHEMBL2774505 | 0.74 | FAAH (0.48) | FAAHCES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2014-02-13 | — | — | US | disclosed |
| US-8372823-B2 | Tetracyclic inhibitors of fatty acid amide hydrolase | THE SCRIPPS RESEARCH INSTITUTE (US) | 2013-02-12 | — | — | US | disclosed |
| EP-2152082-B1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | SCRIPPS RESEARCH INST (US) | 2012-08-29 | — | — | EP | disclosed |
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPS RESEARCH INSTITUTE (US) | 2010-09-30 | — | — | US | disclosed |
| EP-2152082-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | The Scripps Research Institute (US) | 2010-02-17 | — | — | EP | disclosed |
| WO-2008147553-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | THE SCRIPPS RESEARCH INSTITUTE (US) | 2008-12-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100249078-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | FAAH 1/4885CES1 107/4885 |
| US-20140045800-A1 | TETRACYCLIC INHIBITORS OF FATTY ACID AMIDE HYDROLASE | FAAH, FAAH2, APEH | FAAH 1/4885CES1 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.