SCHEMBL27763573

SCHEMBL27763573

CC(=O)OC(C)(C)C.CP(C)(=O)NC(=N)N

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.31
GAA P10253 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid Methyl Ester SCHEMBL27909586 0.83 ALDH1A1 (0.43)
SCHEMBL28010949 0.81 GAA (0.32) GAA
Acetic Acid SCHEMBL28021602 0.78 FFAR3 (0.33)
Guanidine SCHEMBL27275385 0.78 GAA (0.41) DGAT1GAA
SCHEMBL28770788 0.78
Guanidine SCHEMBL27900572 0.76 GAA (0.39) DGAT1GAA
Guanidine SCHEMBL28290227 0.76 GAA (0.39) DGAT1GAA
Acetamide SCHEMBL28017647 0.73 LMNA (0.47) DGAT1GAA
Carbamic Acid SCHEMBL28090504 0.71 GAA (0.42) DGAT1GAA
SCHEMBL6414950 0.71 GAA (0.35) GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101878193-B Bicyclic gamma-amino acid derivatives DAIICHI SANKYO CO LTD 2014-07-09 CN disclosed
CN-103483169-A Bicyclic gamma-amino acid derivative DAIICHI SANKYO CO LTD 2014-01-01 CN disclosed
CN-101878193-A Bicyclic gamma-amino acid derivatives DAIICHI SANKYO CO LTD 2010-11-03 CN disclosed
CN-101460480-A 2-aminopyrimidin-4-ones and their use for treating or preventing a beta-related pathologies ASTRAZENECA AB (SE) 2009-06-17 CN disclosed