Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CHRNB2 | P17787 | 3/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.46 |
| ▸ | TGM2 | P21980 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611770 | 0.87 | MAPT (0.67) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL27765218 | 0.82 | MAPT (0.60) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL4194105 | 0.80 | MAPT (0.65) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL27583941 | 0.80 | SIRT6 (0.60) | MAPTPOLBSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL2401634 | 0.80 | MAPT (0.60) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL521907 | 0.79 | MAPT (0.72) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL1393989 | 0.79 | MAPT (0.67) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL1393988 | 0.79 | MAPT (0.67) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 | |
| SCHEMBL27765461 | 0.79 | TRPC6 (0.44) | MAPTKDM4EALDH1A1GAAKMT2A | |
| SCHEMBL16625907 | 0.78 | MAPT (0.58) | MAPTPOLBSMN1; SMN2RAB9ACHRNB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101594871-B | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG | 2013-06-19 | — | — | CN | disclosed |
| CN-101594871-A | Pyrrolopyrimidine compounds and uses thereof | NOVARTIS AG (CH) | 2009-12-02 | — | — | CN | disclosed |