Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPC6 | Q9Y210 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GCK | P35557 | 2/20 | 0.41 |
| ▸ | GCKR | Q14397 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | F12 | P00748 | 3/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL611676 | 0.83 | KDM4E (0.53) | TRPC6KDM4EALDH1A1GCKGCKR | |
| SCHEMBL30664050 | 0.83 | KDM4E (0.53) | TRPC6KDM4EALDH1A1GCKGCKR | |
| SCHEMBL27563954 | 0.80 | GFER (0.58) | KDM4EALDH1A1KMT2AMAPTPKM | |
| SCHEMBL27765462 | 0.80 | TRPC6 (0.39) | TRPC6KDM4EALDH1A1GCKGCKR | |
| SCHEMBL27765211 | 0.79 | MAPT (0.60) | KDM4EALDH1A1KMT2AMAPTGAA | |
| SCHEMBL29544175 | 0.78 | CASP6 (0.64) | TRPC6KMT2AMAPTCASP6GFER | |
| SCHEMBL2450248 | 0.78 | CASP6 (0.64) | TRPC6KMT2AMAPTCASP6GFER | |
| SCHEMBL27833098 | 0.77 | HRH3 (0.48) | ALDH1A1KMT2AHRH3 | |
| SCHEMBL24375241 | 0.77 | GCK (0.39) | TRPC6KDM4EALDH1A1GCKGCKR | |
| SCHEMBL29600699 | 0.76 | TRPC6 (0.52) | TRPC6ALDH1A1KMT2AGCKGCKR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101594871-B | Pyrrolopyrimidine compounds and their uses | NOVARTIS AG | 2013-06-19 | — | — | CN | disclosed |
| CN-101594871-A | Pyrrolopyrimidine compounds and uses thereof | NOVARTIS AG (CH) | 2009-12-02 | — | — | CN | disclosed |